BMT-124110 (formic)

• Description:

  BMT-124110 formic is a potent, selective AAK1 inhibitor, with an IC50 of 0.9 nM. BMT-124110 shows antinociceptive activity. BMT-124110 formic inhibits BMP-2-inducible protein kinase (BIKE) and Cyclin G-associated kinase (GAK) with IC50s of 17 and 99 nM, respectively[1].

• UNSPSC:

  12352005

• Target:

  AAK1

• Related Pathways:

  Neuronal Signaling

• Field of Research:

  Neurological Disease

• Purity:

  99.17

• Smiles:

  CC (NC1=CC2=C (COC3=CC (OC[C@@] (C) (N) CC (C) C) =CC=C32) C=N1) =O.OC=O

• Molecular Formula:

  C22H29N3O5

• Molecular Weight:

  415.48

• References & Citations:

  [1]Kostich W, et al. Inhibition of AAK1 Kinase as a Novel Therapeutic Approach to Treat Neuropathic Pain. J Pharmacol Exp Ther. 2016 Sep;358 (3) :371-86.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, sealed storage, away from moisture)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported