Products for Research Use Only
RegisterLogin

BMT-090605

CAT: 0804-HY-101290-01Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-101290-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
BMT-090605 is a potent, selective the adapter protein-2 associated kinase 1 (AAK1) inhibitor with an IC50 value of 0.6 nM. BMT-090605 shows antinociceptive activity. BMT-090605 inhibits BMP-2-inducible protein kinase (BIKE) and Cyclin G-associated kinase (GAK) with IC50 values of 45 nM and 60 nM, respectively. BMT-090605 can be used for the research of neuropathic pain[1].
CAS Number
1551403-51-0
UNSPSC
12352005
Target
AAK1; Cyclin G-associated Kinase (GAK)
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/bmt-090605.html
Purity
98.27
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
N#CC1=C(OC[C@@H](N)CC(C)C)C=C(C(C2=CC=NC(C)=C32)=C1)N(C)C3=O
Molecular Formula
C21H24N4O2
Molecular Weight
364.44
References & Citations
[1]Kostich W, et al. Inhibition of AAK1 Kinase as a Novel Therapeutic Approach to Treat Neuropathic Pain. J Pharmacol Exp Ther. 2016 Sep;358 (3) :371-86.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, stored under nitrogen, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

(S)-8-((2-amino-4-methylpentyl)oxy)-4,6-dimethyl-5-oxo-5,6-dihydrobenzo[c][2,7]naphthyridine-9-carbonitrile
CAS Number1551403-51-0
PubChem CID73214233
IUPAC Name8-[(2S)-2-amino-4-methylpentoxy]-4,6-dimethyl-5-oxobenzo[c][2,7]naphthyridine-9-carbonitrile
Molecular FormulaC21H24N4O2
Molecular Weight364.4
XLogP2.5
Topological Polar Surface Area92.2
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count5
Heavy Atom Count27
Formal Charge0
Complexity586
SMILES
CC1=NC=CC2=C1C(=O)N(C3=C2C=C(C(=C3)OC[C@H](CC(C)C)N)C#N)C
InChI
InChI=1S/C21H24N4O2/c1-12(2)7-15(23)11-27-19-9-18-17(8-14(19)10-22)16-5-6-24-13(3)20(16)21(26)25(18)4/h5-6,8-9,12,15H,7,11,23H2,1-4H3/t15-/m0/s1
InChIKey
NQXBZPJVVGIFBJ-HNNXBMFYSA-N
Chemical Structure
2D Structure
2D structure of (S)-8-((2-amino-4-methylpentyl)oxy)-4,6-dimethyl-5-oxo-5,6-dihydrobenzo[c][2,7]naphthyridine-9-carbonitrile
CAS: 1551403-51-0
CID: 73214233
Formula: C21H24N4O2
MW: 364.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight364.4
XLogP32.5
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count5
Exact Mass364.18992602
Monoisotopic Mass364.18992602
Topological Polar Surface Area92.2 Ų
Heavy Atom Count27
Formal Charge0
Complexity586
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Related Products

CatalogName
HY-139205-01BMT-297376
HY-100728-01BMT-145027
HY-117467BMT-108908
HY-171806BMT-136088
HY-124592BMT-052
HY-135871-01BMT-124110
HY-120092BMT-046091
HY-135871A-01BMT-124110 (formic)
HY-100728RBMT-145027 (Standard)
HY-RS01556BMT2 Human Pre-designed siRNA Set A

Alternative Products

CatalogName
MBS5768713BMT-090605
T61941-01BMT-090605 hydrochloride
MBS5800189BMT-297376
MBS5813000BMT-046091
MBS5776598BMT-052
BUP12973-01BMT-145027
GTR19206410-01BMT-124110
GTR19264318-01BMT-136088
GTR19200539-01BMT-108908
TRC-B473771-25MGBMT-153261

Popular Products