BMT-090605

• Target:

  Serine/threonin kinase|||AAK1 (AP2 associated kinase 1) |||Others

• Related Pathways:

  Others|||Cell Cycle/Checkpoint|||Metabolism|||Neuroscience

• Bioactivity:

  BMT-090605 is a potent, selective AAK1 inhibitor with an IC50 of 0.6 nM, and inhibits BMP-2-inducible protein kinase (BIKE) and Cyclin G-associated kinase (GAK) with IC50s of 45 and 60 nM, respectively[1]. BMT-090605 also exhibits antinociceptive activity.

• Smiles:

  CN1C=2C(C=3C(C1=O)=C(C)N=CC3)=CC(C#N)=C(OC[C@H](CC(C)C)N)C2

• Molecular Formula:

  C21H24N4O2

• Molecular Weight:

  364.44

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  1551403-51-0