BMT-124110

• Description :

  BMT-124110 is a potent, selective AAK1 inhibitor with an IC50 of 0.9 nM. BMT-124110 shows antinociceptive activity. BMT-090605 inhibits BMP-2-inducible protein kinase (BIKE) and Cyclin G-associated kinase (GAK) with IC50s of 17 and 99 nM, respectively[1].

• UNSPSC :

  12352005

• Target :

  AAK1

• Type :

  Reference compound

• Related Pathways :

  Neuronal Signaling

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/bmt-124110.html

• Purity :

  99.15

• Solubility :

  10 mM in DMSO

• Smiles :

  CC(NC1=CC2=C(COC3=CC(OC[C@@](C)(N)CC(C)C)=CC=C32)C=N1)=O

• Molecular Formula :

  C21H27N3O3

• Molecular Weight :

  369.46

• References & Citations :

  [1]Kostich W, et al. Inhibition of AAK1 Kinase as a Novel Therapeutic Approach to Treat Neuropathic Pain. J Pharmacol Exp Ther. 2016 Sep;358 (3) :371-86.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C, 3 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [1679371-59-5]