BMT-124110

• UNSPSC Description:

  BMT-124110 is a potent, selective AAK1 inhibitor with an IC50 of 0.9 nM. BMT-124110 shows antinociceptive activity. BMT-090605 inhibits BMP-2-inducible protein kinase (BIKE) and Cyclin G-associated kinase (GAK) with IC50s of 17 and 99 nM, respectively[1].

• Target Antigen:

  AAK1

• Type:

  Reference compound

• Related Pathways:

  Neuronal Signaling

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/bmt-124110.html

• Solubility:

  10 mM in DMSO

• Smiles:

  CC(NC1=CC2=C(COC3=CC(OC[C@@](C)(N)CC(C)C)=CC=C32)C=N1)=O

• Molecular Weight:

  369.46

• References & Citations:

  [1]Kostich W, et al. Inhibition of AAK1 Kinase as a Novel Therapeutic Approach to Treat Neuropathic Pain. J Pharmacol Exp Ther. 2016 Sep;358(3):371-86.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  1679371-59-5