BMT-145027

• Description:

  BMT-145027 is an mGluR5 positive allosteric modulator without inherent agonist activity, exhibits an EC50 of 47 nM.

• UNSPSC:

  12352005

• Target:

  MGluR

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein; Neuronal Signaling

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/BMT-145027.html

• Purity:

  96.10

• Solubility:

  DMSO : 4.35 mg/mL (ultrasonic; warming; heat to 80°C)

• Smiles:

  ClC (C (C (F) (F) F) =C1) =CC=C1C2=NNC3=NC (C4=CC=CC=C4) =C (C#N) C (C5CC5) =C32

• Molecular Formula:

  C23H14ClF3N4

• Molecular Weight:

  438.83

• References & Citations:

  [1]Hill MD, et al. Development of 1H-Pyrazolo[3,4-b]pyridines as Metabotropic Glutamate Receptor 5 Positive Allosteric Modulators. ACS Med Chem Lett. 2016 Oct 3;7 (12) :1082-1086.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  MGluR5

• CAS Number:

  2018282-44-3