BMT-145027

• Description :

  BMT-145027 is an mGluR5 positive allosteric modulator without inherent agonist activity, exhibits an EC50 of 47 nM.

• UNSPSC :

  12352005

• Target :

  MGluR

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein; Neuronal Signaling

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/BMT-145027.html

• Purity :

  96.10

• Solubility :

  DMSO : 4.35 mg/mL (ultrasonic; warming; heat to 80°C)

• Smiles :

  ClC(C(C(F)(F)F)=C1)=CC=C1C2=NNC3=NC(C4=CC=CC=C4)=C(C#N)C(C5CC5)=C32

• Molecular Formula :

  C23H14ClF3N4

• Molecular Weight :

  438.83

• References & Citations :

  [1]Hill MD, et al. Development of 1H-Pyrazolo[3,4-b]pyridines as Metabotropic Glutamate Receptor 5 Positive Allosteric Modulators. ACS Med Chem Lett. 2016 Oct 3;7 (12) :1082-1086.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  MGluR5

• CAS Number :

  [2018282-44-3]