BMS-818251

• Description:

  BMS-818251 is a potent, small-molecule inhibitor of HIV-1 entry with an EC50 value of 0.019 nM. BMS-818251 shows >10-fold higher potency than BMS-626529 (HY-15440) on a cross-clade panel of 208-HIV-1 strains. BMS-818251 interacts with gp120 residues from the conserved β20-β21 hairpin to improve potency[1].

• UNSPSC:

  12352005

• Target:

  HIV

• Related Pathways:

  Anti-infection

• Field of Research:

  Infection

• Smiles:

  N#C/C (C1=CC=CC=C1) =C2CCN (CC/2) C (C (C3=CNC4=C (C5=CSC (C (NCCO) =O) =N5) N=CC (OC) =C34) =O) =O

• Molecular Formula:

  C29H26N6O5S

• Molecular Weight:

  570.62

• References & Citations:

  [1]Lai YT, et al. Lattice engineering enables definition of molecular features allowing for potent small-molecule inhibition of HIV-1 entry. Nat Commun. 2019 Jan 3;10 (1) :47.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  2974489-09-1