BMS-818251

CAT: 0804-HY-125183Size: 1 EachDry Ice: NoHazardous: No

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CAT#:0804-HY-125183Size:1 Each

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Description

BMS-818251 is a potent, small-molecule inhibitor of HIV-1 entry with an EC50 value of 0.019 nM. BMS-818251 shows >10-fold higher potency than BMS-626529 on a cross-clade panel of 208-HIV-1 strains. BMS-818251 interacts with gp120 residues from the conserved β20-β21 hairpin to improve potency[1].

CAS Number

2974489-09-1

UNSPSC

12352005

Target

HIV

Related Pathways

Anti-infection

Field of Research

Infection

Smiles

N#C/C(C1=CC=CC=C1)=C2CCN(CC/2)C(C(C3=CNC4=C(C5=CSC(C(NCCO)=O)=N5)N=CC(OC)=C34)=O)=O

Molecular Formula

C29H26N6O5S

Molecular Weight

570.62

References & Citations

[1]Lai YT, et al. Lattice engineering enables definition of molecular features allowing for potent small-molecule inhibition of HIV-1 entry. Nat Commun. 2019 Jan 3;10 (1) :47.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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T204307-01	BMS-818251
MBS386661-01	BMS-806 (BMS 378806)
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A11201-1	BMS-806 (BMS 378806) 1mg
A11201-500	BMS-806 (BMS 378806) 500mg
A11201-25	BMS-806 (BMS 378806) 25mg
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BMS-818251

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