BMS-344577

• Description:

  BMS-344577 (Compound 22) is a potent and orally active factor Xa inhibitor (IC50 = 4 nM, EC2xPT = 7 μM) . BMS-344577 shows potent CYP3A4 inhibition activity (IC50 = 0.3 μM) . BMS-344577 can be used for the research of cardiovascular disease[1].

• UNSPSC:

  12352005

• Target:

  Cytochrome P450; Factor Xa

• Related Pathways:

  Metabolic Enzyme/Protease

• Field of Research:

  Cardiovascular Disease

• Smiles:

  O=C (N (CCCC1) CC (N2CCCC2) =O) [C@H]1N/C (NC (C3=CN=C (C (N (C) C) =O) C=C3) =O) =N\C4=CC=C (OC (C) =C5) C5=C4

• Molecular Formula:

  C31H37N7O5

• Molecular Weight:

  587.67

• References & Citations:

  [1]Shi Y, et al. Aroylguanidine-based factor Xa inhibitors: the discovery of BMS-344577. Bioorg Med Chem Lett. 2009 Dec 15;19 (24) :6882-9.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  CYP3A4

• CAS Number:

  288079-93-6