BMS-344577

• Description :

  BMS-344577 (Compound 22) is a potent and orally active factor Xa inhibitor (IC50 = 4 nM, EC2xPT = 7 μM) . BMS-344577 shows potent CYP3A4 inhibition activity (IC50 = 0.3 μM) . BMS-344577 can be used for the research of cardiovascular disease[1].

• UNSPSC :

  12352005

• Target :

  Cytochrome P450; Factor Xa

• Related Pathways :

  Metabolic Enzyme/Protease

• Field of Research :

  Cardiovascular Disease

• Smiles :

  O=C(N(CCCC1)CC(N2CCCC2)=O)[C@H]1N/C(NC(C3=CN=C(C(N(C)C)=O)C=C3)=O)=N\C4=CC=C(OC(C)=C5)C5=C4

• Molecular Formula :

  C31H37N7O5

• Molecular Weight :

  587.67

• References & Citations :

  [1]Shi Y, et al. Aroylguanidine-based factor Xa inhibitors: the discovery of BMS-344577. Bioorg Med Chem Lett. 2009 Dec 15;19 (24) :6882-9.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  CYP3A4

• CAS Number :

  [288079-93-6]