BMS-284640

• Description :

  BMS-284640 is a synthetic sodium hydrogen exchange isomer-1 (NHE-1) inhibitor. BMS-284640 has a more than 380-fold higher NHE-1 inhibitory activity (IC50: 9 nM) compared to cariporide (HY-19693) and is more selective for NHE-1 over NHE-2 (IC50: 1.8 μM) and NHE-5 (IC50: 3.36 μM) . BMS-284640 and its analogs also exhibit enhanced oral bioavailability and prolonged plasma half-life in rats.[1].

• CAS Number :

  [230640-88-7]

• UNSPSC :

  12352005

• Target :

  Na+/H+ Exchanger (NHE)

• Type :

  Reference compound

• Related Pathways :

  Membrane Transporter/Ion Channel

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/bms-284640.html

• Purity :

  99.75

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  O=C([C@H]1C(C)(C)[C@@H]1C2=C3CCOC3=CC=C2)NC(N)=N

• Molecular Formula :

  C15H19N3O2

• Molecular Weight :

  273.33

• References & Citations :

  [1]Arylcyclopropanecarboxyl Guanidines as Novel, Potent, and Selective Inhibitors of the Sodium Hydrogen Exchanger Isoform-1

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, sealed storage, away from moisture and light)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported