BMS-846372

• Description:

  BMS-846372 (Compound 5) is an orally active CGRP antagonist (Ki = 0.07 nM) . BMS-846372 may be used in migraine research[1][2].

• UNSPSC:

  12352005

• Target:

  CGRP Receptor

• Related Pathways:

  GPCR/G Protein; Neuronal Signaling

• Field of Research:

  Cardiovascular Disease

• Smiles:

  O=C(N1CCC(N(C2=CC=CN=C2N3)C3=O)CC1)O[C@@H]4CC[C@@H](C5=CC=CC(F)=C5F)CC6=CC=CN=C64

• Molecular Formula:

  C28H27F2N5O3

• Molecular Weight:

  519.54

• References & Citations:

  [1]Leahy DK, et al. Efficient and scalable enantioselective synthesis of a CGRP antagonist. Org Lett. 2012 Sep 21;14 (18) :4938-41.|[2]Luo G, et al. Discovery of BMS-846372, a Potent and Orally Active Human CGRP Receptor Antagonist for the Treatment of Migraine. ACS Med Chem Lett. 2012 Feb 27;3 (4) :337-41.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [1190363-03-1]