AP-22161

• Description :

  AP22161 is a potent and selective Src SH2 domain inhibitor with an IC50 of 0.24 µM. AP22161 exhibits >120-fold selectivity over Yes SH2 (IC50 = 29.38 µM) and ZAP SH2 (IC50 = 421.86 µM) . AP22161 inhibits Src-dependent cellular activity and diminishes osteoclast resorptive activity. AP22161 can be used for osteoporosis research[1].

• CAS Number :

  [268741-42-0]

• UNSPSC :

  12352005

• Target :

  Src

• Related Pathways :

  Protein Tyrosine Kinase/RTK

• Applications :

  Metabolism-protein/nucleotide metabolism

• Field of Research :

  Metabolic Disease

• Smiles :

  O=C(O)C1=CC=C(C[C@H](NC(C)=O)C(N[C@H]2CCCCC3=CC(OCC4CCCCC4)=C(C(N)=O)C=C32)=O)C=C1C=O

• Molecular Formula :

  C32H39N3O7

• Molecular Weight :

  577.67

• References & Citations :

  [1]Violette SM, et al. A Src SH2 selective binding compound inhibits osteoclast-mediated resorption. Chem Biol. 2000 Mar;7 (3) :225-35.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported