INU-101

• Description:

  INU-101 is a potent, selective and orally active 11β-hydroxysteroid dehydrogenase (11β-HSD) type 1 inhibitor. INU-101 has highly potent inhibitory activity in mouse, monkey and human 11β-HSD1, derived from liver microsomes. INU-101 can enhance insulin sensitivity and lower the fasting blood glucose level. INU-101 can be used for the research of metabolic disease, such as diabetes[1].

• UNSPSC:

  12352005

• Target:

  11β-HSD

• Related Pathways:

  Metabolic Enzyme/Protease

• Field of Research:

  Metabolic Disease

• Smiles:

  NC([C@]12C[C@@H](C3)C(NC(C(C)(C)NS(=O)(C4=C(C=CC=C4)F)=O)=O)[C@@H](C[C@@H]3C2)C1)=O

• Molecular Formula:

  C21H28FN3O4S

• Molecular Weight:

  437.53

• References & Citations:

  [1]Hong SP, et al. A novel highly potent and selective 11β-hydroxysteroid dehydrogenase type 1 inhibitor, INU-101. Eur J Pharmacol. 2018 Sep 15;835:169-178.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  1513828-41-5