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INU-152

CAT: 0931-T27614-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T27614-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1380228-30-7
Target
Autophagy, Raf, Apoptosis, Others
Related Pathways
MAPK, Apoptosis, Others, Autophagy
Bioactivity
INU-152 is a pan-RAF inhibitor. INU-152 has potent anti-tumor activity in preclinical models of BRAFV600E mutant cancer. INU-152 inhibits all RAF isoforms and inhibits MAPK pathways in mutant BRAF cells. INU-152 exhibits minimal paradoxical pathway activation in melanoma cells with mutant RAS.
Smiles
N(C1=C(C2=C3C(=NC=N2)N=CN3)C=CC=N1)C4=C(F)C(NS(=O)(=O)C=5C=COC5)=CC=C4F
Molecular Formula
C20H13F2N7O3S
Molecular Weight
469.42
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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