DM-NOFD

• Description :

  DM-NOFD is a cell penetrant, prodrug of NOFD a potent and selective inhibitor of an asparaginyl hydroxylase FIH (factor-inhibiting HIF) [1][2].

• UNSPSC :

  12352005

• Hazard Statement :

  H302-H372-H411

• Target :

  HIF/HIF Prolyl-Hydroxylase

• Related Pathways :

  Metabolic Enzyme/Protease

• Field of Research :

  Cancer

• Smiles :

  COC(C(N[C@@H](C(OC)=O)CC1=CC=CC=C1)=O)=O

• Molecular Formula :

  C13H15NO5

• Molecular Weight :

  265.26

• Precautions :

  P260-P264-P273-P391-P501

• References & Citations :

  [1]Luczak MW, Krawic C, Zhitkovich A. NAD+ metabolism controls growth inhibition by HIF1 in normoxia and determines differential sensitivity of normal and cancer cells. Cell Cycle. 2021 Sep;20 (18) :1812-1827.|[2]Corner TP, et al. Structure-guided optimisation of N-hydroxythiazole-derived inhibitors of factor inhibiting hypoxia-inducible factor-α. Chem Sci. 2023 Oct 27;14 (43) :12098-12120.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [865488-53-5]