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DM-4103

CAT: 0804-HY-W702907Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-W702907Size:1 Each
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Description
DM-4103 is a major metabolite of Tolvaptan that is metabolized primarily by the CYP3A4 enzyme in the liver. DM-4103 inhibits the ability of human liver transporters NTCP, BSEP, MRP2, MRP3, MRP4 (IC50 values are 16.3, 4.15, 51.0, 44.6, 4.26 μM, respectively) and bile acid transport in SCHH cells. DM-4103 can be used in the study of autosomal dominant polycystic kidney disease (ADPKD)[2].
CAS Number
1346599-56-1
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
P-glycoprotein
Related Pathways
Membrane Transporter/Ion Channel
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Smiles
CC1=CC=CC=C1C(NC2=CC(C)=C(C(NC3=C(C(CCC(O)=O)=O)C=C(Cl)C=C3)=O)C=C2)=O
Molecular Formula
C26H23ClN2O5
Molecular Weight
478.92
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Wan W L, et al. Synthesis of the major metabolites of Tolvaptan[J]. Chinese Chemical Letters, 2012, 23 (12) : 1343-1346.|[2]Slizgi JR, et al. Inhibition of Human Hepatic Bile Acid Transporters by Tolvaptan and Metabolites: Contributing Factors to Drug-Induced Liver Injury? Toxicol Sci. 2016 Jan;149 (1) :237-50.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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