Tomaymycin DM

• Description:

  Tomaymycin DM is a tomaymycin derivative, PBD monomer, and DNA alkylating agent. Tomaymycin DM can serve as a payload in tumor-targeting antibody-conjugated active molecules (ADCs) .

• UNSPSC:

  12352203

• Target:

  ADC Payload

• Type:

  ADC Related

• Related Pathways:

  Antibody-drug Conjugate/ADC Related

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/Tomaymycin_DM.html

• Purity:

  95.73

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  O=C1N2[C@](CC(C2)=C)([H])C=NC3=CC(O)=C(OC)C=C13

• Molecular Formula:

  C14H14N2O3

• Molecular Weight:

  258.27

• References & Citations:

  [1]Dr. Julia Mantaj, et al. From Anthramycin to Pyrrolobenzodiazepine (PBD) -Containing Antibody–Drug Conjugates (ADCs) . Angew Chem Int Ed Engl. 2017 Jan 9; 56 (2) : 462–488.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C (Powder, stored under nitrogen)

• Scientific Category:

  ADC Related

• Clinical Information:

  No Development Reported

• Isoform:

  Pyrrolobenzodiazepines

• CAS Number:

  [945490-09-5]