Ganoderic acid DM

CAT: 0804-HY-120140-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-120140-01Size:1 mg
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Description
Ganoderic acid DM, a natural triterpenoid isolated from Ganoderma lucidum, induces DNA damage, G1 cell cycle arrest and apoptosis in human breast cancer cells. Ganoderic acid DM as a specific inhibitor of osteoclastogenesis[1][2].
CAS Number
[173075-45-1]
UNSPSC
12352211
Hazard Statement
H315, H319, H335
Target
Apoptosis; PI3K
Type
Natural Products
Related Pathways
Apoptosis; PI3K/Akt/mTOR
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Cancer; Metabolic Disease; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/ganoderic-acid-dm.html
Purity
99.9
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
C[C@]12C3=C(CC[C@@]1([C@@](CC2)([H])[C@H](C)CC/C=C(C)/C(O)=O)C)[C@@]4([C@@](C(C)(C(CC4)=O)C)([H])CC3=O)C
Molecular Formula
C30H44O4
Molecular Weight
468.67
Precautions
H315, H319, H335
References & Citations
[1]Guo-Sheng Wu, et al. Ganoderic acid DM, a natural triterpenoid, induces DNA damage, G1 cell cycle arrest and apoptosis in human breast cancer cells. Fitoterapia. 2012 Mar;83 (2) :408-14.|[2]Ichiko Miyamoto, et al. Regulation of osteoclastogenesis by ganoderic acid DM isolated from Ganoderma lucidum. Eur J Pharmacol. 2009 Jan 5;602 (1) :1-7.|[3]Junbo Xia, et al. Ganoderic acid DM induces autophagic apoptosis in non-small cell lung cancer cells by inhibiting the PI3K/Akt/mTOR activity. Chem Biol Interact. 2020 Jan 25;316:108932.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported

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