Ganoderic acid DM

• Description :

  Ganoderic acid DM, a natural triterpenoid isolated from Ganoderma lucidum, induces DNA damage, G1 cell cycle arrest and apoptosis in human breast cancer cells. Ganoderic acid DM as a specific inhibitor of osteoclastogenesis[1][2].

• UNSPSC :

  12352211

• Hazard Statement :

  H315, H319, H335

• Target :

  Apoptosis; PI3K

• Type :

  Natural Products

• Related Pathways :

  Apoptosis; PI3K/Akt/mTOR

• Applications :

  Metabolism-sugar/lipid metabolism

• Field of Research :

  Cancer; Metabolic Disease; Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/ganoderic-acid-dm.html

• Purity :

  99.9

• Solubility :

  DMSO : 50 mg/mL (ultrasonic)

• Smiles :

  C[C@]12C3=C(CC[C@@]1([C@@](CC2)([H])[C@H](C)CC/C=C(C)/C(O)=O)C)[C@@]4([C@@](C(C)(C(CC4)=O)C)([H])CC3=O)C

• Molecular Formula :

  C30H44O4

• Molecular Weight :

  468.67

• Precautions :

  H315, H319, H335

• References & Citations :

  [1]Guo-Sheng Wu, et al. Ganoderic acid DM, a natural triterpenoid, induces DNA damage, G1 cell cycle arrest and apoptosis in human breast cancer cells. Fitoterapia. 2012 Mar;83 (2) :408-14.|[2]Ichiko Miyamoto, et al. Regulation of osteoclastogenesis by ganoderic acid DM isolated from Ganoderma lucidum. Eur J Pharmacol. 2009 Jan 5;602 (1) :1-7.|[3]Junbo Xia, et al. Ganoderic acid DM induces autophagic apoptosis in non-small cell lung cancer cells by inhibiting the PI3K/Akt/mTOR activity. Chem Biol Interact. 2020 Jan 25;316:108932.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, protect from light)

• Scientific Category :

  Natural Products

• Clinical Information :

  No Development Reported

• CAS Number :

  [173075-45-1]