DM-4111

• Description :

  DM-4111, one of the major monohydroxyl metabolites of Tolvaptan (HY-17000), is a potent vasopressin V2 receptor inhibitor. DM-4111 inhibits water reabsorption in the renal tubules, thereby promoting the excretion of electrolyte-free water. DM-4111 is promising for research of cardiovascular diseases[1][2].

• UNSPSC :

  12352005

• Target :

  Drug Metabolite; Vasopressin Receptor

• Related Pathways :

  GPCR/G Protein; Metabolic Enzyme/Protease

• Field of Research :

  Cardiovascular Disease

• Smiles :

  O=C(NC1=CC=C(C(N2CC[C@H](O)[C@H](O)C3=CC(Cl)=CC=C32)=O)C(C)=C1)C4=CC=CC=C4C

• Molecular Formula :

  C26H25ClN2O4

• Molecular Weight :

  464.94

• References & Citations :

  [1]Hoshikawa K, et al. Validated liquid chromatography coupled to tandem mass spectrometry method for simultaneous quantitation of tolvaptan and its five major metabolites in human plasma. Ann Clin Biochem. 2019 May;56 (3) :387-396.|[2]Hoshikawa K, et al. Impact of CYP3A5 genotype on tolvaptan pharmacokinetics and their relationships with endogenous markers of CYP3A activity and serum sodium level in heart failure patients. Basic Clin Pharmacol Toxicol. 2020 Apr;126 (4) :353-363.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  V2 Receptor

• CAS Number :

  [926035-36-1]