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P-8977

CAT: 0804-HY-108109Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-108109Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
P-8977 is a potent dual CO/5-LO inhibitor (IC50 = 0.01 µM) . P-8977 can also inhibit cyclooxygenase (CO) (IC50 = 0.53 µM) in 3T3 cells. P-8977 can inhibit ear edema. P-8977 can be used for research on inflammatory skin conditions[1].
CAS Number
135810-00-3
UNSPSC
12352005
Target
COX; Lipoxygenase
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease
Field of Research
Inflammation/Immunology
Smiles
O=C1C2=C(COC3=CC=C(CCC(N(C)O)=O)C=C13)C=CC=C2
Molecular Formula
C18H17NO4
Molecular Weight
311.33
References & Citations
[1]Hamer RR, et al. Dibenzoxepinone hydroxylamines and hydroxamic acids: dual inhibitors of cyclooxygenase and 5-lipoxygenase with potent topical antiinflammatory activity. J Med Chem. 1996 Jan 5;39 (1) :246-52.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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