U 93385

• Description :

  U93385 is a 5-HT₁A receptor agonist. U93385 exhibits no significant α₂ adrenergic, D₂ dopamine, or other receptor activities. U93385 has a heart rate regulating effect, stimulating the vagus nerve to induce bradycardia. U93385 can be used to study the 5-HT₁A receptor-mediated vagal nerve tolerance mechanism[1].

• UNSPSC :

  12352005

• Target :

  5-HT Receptor

• Related Pathways :

  GPCR/G Protein; Neuronal Signaling

• Field of Research :

  Neurological Disease

• Smiles :

  NC(C1=C2[C@@]3([H])[C@](CCC2=CC=C1)([H])N(CCC)CC3)=O

• Molecular Formula :

  C16H22N2O

• Molecular Weight :

  258.36

• References & Citations :

  [1]McCall RB, et al. Rapid and long duration tolerance to the vagal bradycardic effects of 5-HT1A receptor agonists. Behav Brain Res. 1996;73 (1-2) :297-300.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  Phase 1

• Isoform :

  5-HT1 Receptor

• CAS Number :

  [147145-16-2]