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BMS-184476

CAT: 0804-HY-106176Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-106176Size:1 Each
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Description
BMS-184476 is a selective microtubule inhibitor with potent antitumor activity. BMS-184476 induces G2/M phase arrest and promotes tumor cell apoptosis. BMS-184476 is promising for research of solid tumors, such as non-small cell lung cancer[1].
CAS Number
160237-25-2
UNSPSC
12352005
Target
Microtubule/Tubulin
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
CC(O[C@]12[C@]([C@@H]3OC(C4=CC=CC=C4)=O)([H])[C@@]([C@@H](OCSC)C[C@@]1([H])OC2)(C([C@@H](C5=C(C)[C@@H](OC([C@H](O)[C@H](C6=CC=CC=C6)NC(C7=CC=CC=C7)=O)=O)C[C@]3(O)C5(C)C)OC(C)=O)=O)C)=O
Molecular Formula
C49H55NO14S
Molecular Weight
914.02
References & Citations
[1]Kim JS, et al. The novel taxane analogs, BMS-184476 and BMS-188797, potentiate the effects of radiation therapy in vitro and in vivo against human lung cancer cells. Int J Radiat Oncol Biol Phys. 2001 Oct 1;51 (2) :525-34.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2

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