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GRL-8234

CAT: 0804-HY-10104Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-10104Size:1 Each
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Description
GRL-8234 is a potent β-secretase (BACE1) inhibitor with blood-brain barrier penetration (Ki = 1.8 nM) . GRL-8234 can rescue age-related cognitive decline in Tg2576 mice. GRL-8234 can be used in the research related to Alzheimer's disease (AD) [1].
CAS Number
913071-81-5
UNSPSC
12352005
Target
Beta-secretase
Related Pathways
Neuronal Signaling
Field of Research
Neurological Disease
Smiles
O=S(N(C)C1=CC(C(N[C@@H](CC2=CC=CC=C2)[C@@H](CNCC3=CC(OC)=CC=C3)O)=O)=CC(C(N[C@H](C)C4=CC=CC=C4)=O)=C1)(C)=O
Molecular Formula
C36H42N4O6S
Molecular Weight
658.81
References & Citations
[1]Chang WP, et al. Beta-secretase inhibitor GRL-8234 rescues age-related cognitive decline in APP transgenic mice. FASEB J. 2011 Feb;25 (2) :775-84.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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