GRL-8234

• Description:

  GRL-8234 is a potent β-secretase (BACE1) inhibitor with blood-brain barrier penetration (Ki = 1.8 nM) . GRL-8234 can rescue age-related cognitive decline in Tg2576 mice. GRL-8234 can be used in the research related to Alzheimer's disease (AD) [1].

• UNSPSC:

  12352005

• Target:

  Beta-secretase

• Related Pathways:

  Neuronal Signaling

• Field of Research:

  Neurological Disease

• Smiles:

  O=S(N(C)C1=CC(C(N[C@@H](CC2=CC=CC=C2)[C@@H](CNCC3=CC(OC)=CC=C3)O)=O)=CC(C(N[C@H](C)C4=CC=CC=C4)=O)=C1)(C)=O

• Molecular Formula:

  C36H42N4O6S

• Molecular Weight:

  658.81

• References & Citations:

  [1]Chang WP, et al. Beta-secretase inhibitor GRL-8234 rescues age-related cognitive decline in APP transgenic mice. FASEB J. 2011 Feb;25 (2) :775-84.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [913071-81-5]