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GRL-190-21

CAT: 0804-HY-162229Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-162229Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
GRL-190-21 (compound 5e) is an inhibitor for SARS-Cov-2-Mpro with a Ki of 0.04 nM and exhibits antiviral activity in VeroE6 cells with EC50 of 0.26 μM. GRL-190-21 reduces the infectivity, replication, and cytopathic effect of SARS-CoV-2 without significant toxicity[1].
CAS Number
2755957-14-1
UNSPSC
12352005
Target
SARS-CoV
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/grl-190-21.html
Solubility
10 mM in DMSO
Smiles
O=C(N[C@@H](C(C)(C)C)C(N1[C@H](C(N[C@@H](C[C@@]2([H])C(NCCC2)=O)C#N)=O)[C@]3([H])[C@](C3(C)C)([H])C1)=O)C(F)(F)F
Molecular Formula
C24H34F3N5O4
Molecular Weight
513.55
References & Citations
[1]Ghosh AK, et al., Exploration of P1 and P4 modifications of nirmatrelvir: Design, synthesis, biological evaluation, and X-ray structural studies of SARS-CoV-2 Mpro inhibitors. Eur J Med Chem. 2024 Feb 1;267:116132.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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