RegisterLogin

GRL-07524

CAT: 0804-HY-175031Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-175031Size:1 Each
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
GRL-07524 (Compound 4e) is a potent inhibitor of HIV-1 protease (Ki = 0.22 nM) . GRL-07524 contains oxaspirocyclic carbamates as the P2 ligands. GRL-07524 exhibits good antiviral activity with an EC50 = 210 nM. GRL-07524 binds to the HIV-1 PR active site in one of the four symmetry independent molecules along with key catalytic residues[1].
UNSPSC
12352005
Target
HIV Protease
Related Pathways
Anti-infection; Metabolic Enzyme/Protease
Field of Research
Infection
Smiles
COC1=CC=C(C=C1)S(=O)(N(CC(C)C)C[C@@H](O)[C@@H](NC(O[C@H]2CCC[C@@]23C[C@@H](C4=C(C=CC=C4)OC)OCC3)=O)CC5=CC=CC=C5)=O
Molecular Formula
C38H50N2O8S
Molecular Weight
694.88
References & Citations
[1]Ghosh, A. K., et al., (2025) . Design, synthesis, evaluation and X-ray structural studies of potent HIV-1 protease inhibitors containing substituted oxaspirocyclic carbamates as the P2 ligands. European journal of medicinal chemistry, 297, 117880. Advance online publication.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Related Products

CatalogName
HY-137954-01GRL-0496
HY-153533-01GRL-1720
HY-10104GRL-8234
HY-179707GRL-03022
HY-153533A-01GRL-1720 (TFA)
HY-162229GRL-190-21
HY-174256GRL-098-22
HY-10974-01MK-0752
HY-10975MK-0752 (sodium)

Alternative Products

CatalogName
T211768-01GRL-07524
7280/25GRL 0617
abx283284-01GRL-0667
MBS5811970GRL-98065
MBS5812081GRL-0820
MBS3607088GRL-079
bs-83072C-01GRL-0496
T68377-01GRL-8234
MBS133644GRL-1720
bs-83075C-01GRL-0617

Popular Products