GR 82334

• UNSPSC Description:

  GR 82334 is a potent and specific reversible tachykinin NK1 receptor antagonist[1]. GR 82334 inhibits substance P-induced sensitization by blocking SP NK1 receptors in naked mole-rats[1].

• Target Antigen:

  Others

• Type:

  Peptides

• Related Pathways:

  Others

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/gr-82334.html

• Solubility:

  10 mM in DMSO

• Smiles:

  OC(C=C1)=CC=C1C[C@H](NC([C@@H](NC([C@H](CCCCN)NC([C@H](CC(N)=O)NC([C@H]2N(CCC2)C([C@H](CC(O)=O)NC([C@H](C)NC([C@@H]3CCC(N3)=O)=O)=O)=O)=O)=O)=O)CC4=CC=CC=C4)=O)C(N5[C@]6(CCC5)C(N(CC6)[C@@H](CC(C)C)C(N[C@H](C(N)=O)CC7=CNC8=CC=CC=C78)=O)=O)=O

• Molecular Weight:

  1386.55

• References & Citations:

  [1]A Lecci,et al.Effect of the NK-1 receptor antagonist GR 82,334 on reflexly-induced bladder contractions. Life Sci|[2]Antje Brand, et al.  Functional neurokinin and NMDA receptor activity in an animal naturally lacking substance P: the naked mole-rat.PLoS One. 2010 Dec 21;5(12):e15162.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  129623-01-4