GRL-0496

• UNSPSC Description:

  GRL-0496 is a potent chloropyridyl ester-derived SARS-CoV 3CLpro inhibitor, with an IC50 of 30 nM in both enzyme inhibitory and antiviral assays. GRL-0496 shows SARS-CoV antiviral activity, with an EC50 of 6.9 μM[1].

• Target Antigen:

  SARS-CoV

• Type:

  Reference compound

• Related Pathways:

  Anti-infection

• Field of Research:

  Infection

• Assay Protocol:

  https://www.medchemexpress.com/grl-0496.html

• Smiles:

  O=C(C1=CC=CC2=C1C=CN2)OC3=CC(Cl)=CN=C3

• Molecular Weight:

  272.69

• References & Citations:

  [1]Ghosh AK, et, al. Design, synthesis and antiviral efficacy of a series of potent chloropyridyl ester-derived SARS-CoV 3CLpro inhibitors. Bioorg Med Chem Lett. 2008 Oct 15;18(20):5684-8.

• Shipping Conditions:

  Room Temperature

• CAS Number:

  1087243-14-8