GRL-03022

• Description :

  GRL-03022 is a potent, selective and non-covalent G protein-coupled receptor kinase 5 (GRK5) inhibitor with an IC50 of 60 nM. GRL-03022 exhibits >16000-fold selectivity over GRK2 (IC50 > 1000 μM) . GRL-03022 can be used for heart failure and cancer research[1].

• UNSPSC :

  12352005

• Target :

  G Protein-coupled Receptor Kinase (GRK)

• Related Pathways :

  GPCR/G Protein

• Field of Research :

  Cancer; Cardiovascular Disease

• Smiles :

  O=C(C1=CC2=C(NC(/C2=C\C3=C(C)C(C(N[C@@H](C)COC)=O)=C(C)N3)=O)C=C1)N[C@@H](C4=CC=CC=C4)C

• Molecular Formula :

  C29H32N4O4

• Molecular Weight :

  500.59

• References & Citations :

  [1]Ghosh AK, et al. Potent, Selective, and Drug-Like G Protein-Coupled Receptor Kinase 5 and 6 Inhibitors: Design, Synthesis, and X-Ray Structural Studies. ChemMedChem. 2025 Oct 15;20 (20) :e202500257.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  GRK2; GRK5