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MK-8617 (Standard)

CAT: 0804-HY-101023RSize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-101023RSize:1 Each
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Description
MK-8617 (Standard) is the analytical standard of MK-8617. This product is intended for research and analytical applications. MK-8617 is an orally active pan-inhibitor of hypoxia-inducible factor prolyl hydroxylase 1-3 (HIF PHD1-3) with an IC50 of 1 nM for PHD2.
CAS Number
1187990-87-9
Target
HIF/HIF Prolyl-Hydroxylase; Reference Standards
Related Pathways
Metabolic Enzyme/Protease; Others
Field of Research
Inflammation/Immunology
Smiles
O=C(C1=CN=C(C2=NN=CC=C2)N=C1O)NC(C3=CC=C(OC)C=C3)C4=CC=C(OC)C=C4
Molecular Formula
C24H21N5O4
Molecular Weight
443.45
References & Citations
[1]Debenham JS, et al. Discovery of N-[Bis (4-methoxyphenyl) methyl]-4-hydroxy-2- (pyridazin-3-yl) pyrimidine-5-carboxamide (MK-8617), an Orally Active Pan-Inhibitor of Hypoxia-Inducible Factor Prolyl Hydroxylase 1-3 (HIF PHD1-3) for the Treatment of Anemia. J Med Chem. 2016 Dec 22;59 (24) :11039-11049.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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