MK-8617 (Standard)

• Description:

  MK-8617 (Standard) is the analytical standard of MK-8617 (HY-101023) . This product is intended for research and analytical applications. MK-8617 is an orally active pan-inhibitor of hypoxia-inducible factor prolyl hydroxylase 1-3 (HIF PHD1-3) with an IC50 of 1 nM for PHD2.

• Target:

  HIF/HIF Prolyl-Hydroxylase; Reference Standards

• Related Pathways:

  Metabolic Enzyme/Protease; Others

• Field of Research:

  Inflammation/Immunology

• Smiles:

  O=C (C1=CN=C (C2=NN=CC=C2) N=C1O) NC (C3=CC=C (OC) C=C3) C4=CC=C (OC) C=C4

• Molecular Formula:

  C24H21N5O4

• Molecular Weight:

  443.45

• References & Citations:

  [1]Debenham JS, et al. Discovery of N-[Bis (4-methoxyphenyl) methyl]-4-hydroxy-2- (pyridazin-3-yl) pyrimidine-5-carboxamide (MK-8617), an Orally Active Pan-Inhibitor of Hypoxia-Inducible Factor Prolyl Hydroxylase 1-3 (HIF PHD1-3) for the Treatment of Anemia. J Med Chem. 2016 Dec 22;59 (24) :11039-11049.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference Standards

• CAS Number:

  1187990-87-9