MK-4101 (Standard)

• Description:

  MK-4101 (Standard) is the analytical standard of MK-4101 (HY-100036) . This product is intended for research and analytical applications. MK-4101 is a Smoothened (SMO) antagonist (IC50 of 1.1 μM for 293 cells) and also a potent inhibitor of the hedgehog pathway (IC50 of 1.5 μM for mouse cells; IC50 of 1 μM for KYSE180 oesophageal cancer cells) . MK-4101 has robust antitumor activity that inhibits tumor cell proliferation and induces extensive apoptosis[1].

• Target:

  Apoptosis; Hedgehog; Reference Standards; Smo

• Related Pathways:

  Apoptosis; Others; Stem Cell/Wnt

• Field of Research:

  Cancer

• Smiles:

  FC(C1=CC=CC=C1C2=NN=C(C34CCC(C5=NOC(C6CC(F)(F)C6)=N5)(CC4)CC3)N2C)(F)F

• Molecular Formula:

  C24H24F5N5O

• Molecular Weight:

  493.47

• References & Citations:

  [1]Filocamo G et al. MK-4101, a Potent Inhibitor of the Hedgehog Pathway, Is Highly Active against Medulloblastoma and Basal Cell Carcinoma. Mol Cancer Ther. 2016 Jun;15 (6) :1177-89.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference Standards

• CAS Number:

  [935273-79-3]