MK-8617

• Description :

  MK-8617 is an orally active pan-inhibitor of hypoxia-inducible factor prolyl hydroxylase 1-3 (HIF PHD1-3) with an IC50 of 1 nM for PHD2.

• CAS Number :

  [1187990-87-9]

• UNSPSC :

  12352005

• Hazard Statement :

  H315, H317, H318, H334, H335, H341, H361, H370, H413

• Target :

  HIF/HIF Prolyl-Hydroxylase

• Type :

  Reference compound

• Related Pathways :

  Metabolic Enzyme/Protease

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/MK-8617.html

• Purity :

  99.92

• Solubility :

  DMSO : 5.71 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles :

  O=C(C1=CN=C(C2=NN=CC=C2)N=C1O)NC(C3=CC=C(OC)C=C3)C4=CC=C(OC)C=C4

• Molecular Formula :

  C24H21N5O4

• Molecular Weight :

  443.45

• Precautions :

  H315, H317, H318, H334, H335, H341, H361, H370, H413

• References & Citations :

  [1]Debenham JS, et al. Discovery of N-[Bis (4-methoxyphenyl) methyl]-4-hydroxy-2- (pyridazin-3-yl) pyrimidine-5-carboxamide (MK-8617), an Orally Active Pan-Inhibitor of Hypoxia-Inducible Factor Prolyl Hydroxylase 1-3 (HIF PHD1-3) for the Treatment of Anemia. J Med Chem. 2016 Dec 22;59 (24) :11039-11049.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported