Products for Research Use Only
RegisterLogin

MK-8617

CAT: 0804-HY-101023-01Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-101023-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
MK-8617 is an orally active pan-inhibitor of hypoxia-inducible factor prolyl hydroxylase 1-3 (HIF PHD1-3) with an IC50 of 1 nM for PHD2.
CAS Number
1187990-87-9
UNSPSC
12352005
Hazard Statement
H315, H317, H318, H334, H335, H341, H361, H370, H413
Target
HIF/HIF Prolyl-Hydroxylase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/MK-8617.html
Purity
99.92
Solubility
DMSO : 5.71 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(C1=CN=C(C2=NN=CC=C2)N=C1O)NC(C3=CC=C(OC)C=C3)C4=CC=C(OC)C=C4
Molecular Formula
C24H21N5O4
Molecular Weight
443.45
Precautions
H315, H317, H318, H334, H335, H341, H361, H370, H413
References & Citations
[1]Debenham JS, et al. Discovery of N-[Bis (4-methoxyphenyl) methyl]-4-hydroxy-2- (pyridazin-3-yl) pyrimidine-5-carboxamide (MK-8617), an Orally Active Pan-Inhibitor of Hypoxia-Inducible Factor Prolyl Hydroxylase 1-3 (HIF PHD1-3) for the Treatment of Anemia. J Med Chem. 2016 Dec 22;59 (24) :11039-11049.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Related Products

CatalogName
HY-158128-01MK-8527
HY-158316BTL-MK
HY-19914-01MK-1064
HY-14166-01MK-886
HY-11027-01MK-0773
HY-11070-01MK-0952
HY-13299-01MK-8033
HY-10413-01MK-2894
HY-108232-01MK-2206
HY-117967MK-6169

Alternative Products

CatalogName
BA7798-5MK-8617
BM170837-01MK 8617

Popular Products