MK-8617

• Description:

  MK-8617 is an orally active pan-inhibitor of hypoxia-inducible factor prolyl hydroxylase 1-3 (HIF PHD1-3) with an IC50 of 1 nM for PHD2.

• UNSPSC:

  12352005

• Hazard Statement:

  H315, H317, H318, H334, H335, H341, H361, H370, H413

• Target:

  HIF/HIF Prolyl-Hydroxylase

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/MK-8617.html

• Purity:

  99.92

• Solubility:

  DMSO : 5.71 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles:

  O=C (C1=CN=C (C2=NN=CC=C2) N=C1O) NC (C3=CC=C (OC) C=C3) C4=CC=C (OC) C=C4

• Molecular Formula:

  C24H21N5O4

• Molecular Weight:

  443.45

• Precautions:

  H315, H317, H318, H334, H335, H341, H361, H370, H413

• References & Citations:

  [1]Debenham JS, et al. Discovery of N-[Bis (4-methoxyphenyl) methyl]-4-hydroxy-2- (pyridazin-3-yl) pyrimidine-5-carboxamide (MK-8617), an Orally Active Pan-Inhibitor of Hypoxia-Inducible Factor Prolyl Hydroxylase 1-3 (HIF PHD1-3) for the Treatment of Anemia. J Med Chem. 2016 Dec 22;59 (24) :11039-11049.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  1187990-87-9