SR-3029 (Standard)

• Description :

  SR-3029 (Standard) is the analytical standard of SR-3029 (HY-100011) . This product is intended for research and analytical applications. SR-3029 is a potent and ATP competitive CK1δ and CK1ε inhibitor, with IC50s of 44 nM and 260 nM, respectively, and Kis of 97 nM for both kinases.

• Target :

  Casein Kinase; Reference Standards

• Related Pathways :

  Cell Cycle/DNA Damage; Others; Stem Cell/Wnt

• Field of Research :

  Cancer

• Smiles :

  FC1=CC(N2C=NC3=C(NCC4=NC5=CC=C(F)C(F)=C5N4)N=C(N6CCOCC6)N=C23)=CC=C1

• Molecular Formula :

  C23H19F3N8O

• Molecular Weight :

  480.45

• References & Citations :

  [1]Bibian M, et al. Development of highly selective casein kinase 1δ/1ε (CK1δ/ε) inhibitors with potent antiproliferative properties. Bioorg Med Chem Lett. 2013 Aug 1;23 (15) :4374-80.|[2]Rosenberg LH, et al. Therapeutic targeting of casein kinase 1δ in breast cancer. Sci Transl Med. 2015 Dec 16;7 (318) :318ra202.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference Standards

• CAS Number :

  [1454585-06-8]