SR-302

• Description :

  SR-302, a chemical probe, is a potent and selectivity DDR/p38 inhibitor, with IC50 values of 0.125, 0.023 and 0.018 μM for p38α, DDR1 and DDR2, respectively. SR-302 can be used for the research of fibrotic disorders, such as renal and pulmonary fibrosis, atherosclerosis, and various forms of cancer[1].

• UNSPSC :

  12352005

• Target :

  Discoidin Domain Receptor; p38 MAPK

• Related Pathways :

  MAPK/ERK Pathway; Protein Tyrosine Kinase/RTK

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Cancer; Inflammation/Immunology

• Purity :

  98.51

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  CS(N(CCC1)CC1NC([C@H](CCC2CCCCC2)NC(C(C=C3)=CC=C3CNC(C4=CN=C5N4C=CC=C5)=O)=O)=O)(=O)=O

• Molecular Formula :

  C32H42N6O5S

• Molecular Weight :

  622.78

• References & Citations :

  [1]Röhm S, et al. Development of a Selective Dual Discoidin Domain Receptor (DDR) /p38 Kinase Chemical Probe. J Med Chem. 2021 Sep 23;64 (18) :13451-13474.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  DDR1; DDR2; p38α

• CAS Number :

  [2771319-74-3]