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SR-302

CAT: 0804-HY-167208-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-167208-01Size:5 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SR-302, a chemical probe, is a potent and selectivity DDR/p38 inhibitor, with IC50 values of 0.125, 0.023 and 0.018 μM for p38α, DDR1 and DDR2, respectively. SR-302 can be used for the research of fibrotic disorders, such as renal and pulmonary fibrosis, atherosclerosis, and various forms of cancer[1].
CAS Number
[2771319-74-3]
UNSPSC
12352005
Target
Discoidin Domain Receptor; p38 MAPK
Related Pathways
MAPK/ERK Pathway; Protein Tyrosine Kinase/RTK
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Purity
98.51
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CS(N(CCC1)CC1NC([C@H](CCC2CCCCC2)NC(C(C=C3)=CC=C3CNC(C4=CN=C5N4C=CC=C5)=O)=O)=O)(=O)=O
Molecular Formula
C32H42N6O5S
Molecular Weight
622.78
References & Citations
[1]Röhm S, et al. Development of a Selective Dual Discoidin Domain Receptor (DDR) /p38 Kinase Chemical Probe. J Med Chem. 2021 Sep 23;64 (18) :13451-13474.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
DDR1; DDR2; p38α

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