SR 146131

• Description :

  SR 146131 is a potent, orally available, and selective nonpeptide (cholecystokinin 1) receptor agonist.

• CAS Number :

  [221671-61-0]

• UNSPSC :

  12352005

• Target :

  Cholecystokinin Receptor

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein; Neuronal Signaling

• Applications :

  Metabolism-protein/nucleotide metabolism

• Field of Research :

  Metabolic Disease; Endocrinology

• Assay Protocol :

  https://www.medchemexpress.com/SR_146131.html

• Purity :

  98.23

• Solubility :

  DMSO : 250 mg/mL (ultrasonic)

• Smiles :

  O=C(O)CN1C(C(NC2=NC(C3=CC(OC)=C(Cl)C=C3OC)=C(CCC4CCCCC4)S2)=O)=CC5=C1C(C)=CC(C)=C5

• Molecular Formula :

  C32H36ClN3O5S

• Molecular Weight :

  610.16

• References & Citations :

  [1]Bignon E, et al. SR146131: a new potent, orally active, and selective nonpeptide cholecystokinin subtype 1 receptor agonist. I. In vitro studies. J Pharmacol Exp Ther. 1999 May;289 (2) :742-51.|[2]Bignon E, et al. SR146131: a new potent, orally active, and selective nonpeptide cholecystokinin subtype 1 receptor agonist. II. In vivo pharmacological characterization. J Pharmacol Exp Ther. 1999 May;289 (2) :752-61.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Phase 1

• Isoform :

  CCKAR