SR 11023

• UNSPSC Description:

  SR 11023 is an orally active antagonist of PPARγ, with the IC50 value of 109 nM that plays an important role in diabetic research[1].

• Target Antigen:

  PPAR

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage;Metabolic Enzyme/Protease;Vitamin D Related/Nuclear Receptor

• Applications:

  Metabolism-protein/nucleotide metabolism

• Field of Research:

  Metabolic Disease

• Assay Protocol:

  https://www.medchemexpress.com/sr-11023.html

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  C[C@@H](C1=CC(C2CC2)=CC=C1)NC(C3=CC=C(C(C(C)=C4C)=C3)N4CC5=CC=C(C=C5)C(C)(C)C(O)=O)=O

• Molecular Weight:

  508.65

• References & Citations:

  [1]J Mukherjee, et al. Chemical Crosslinking Mass Spectrometry Reveals the Conformational Landscape of the Activation Helix of PPARγ; a Model for Ligand-Dependent Antagonism. Nucl Med Biol. 1995 Apr;22(3):283-96.

• Shipping Conditions:

  Room Temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  1820602-13-8