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SR 11023

CAT: 0804-HY-160162-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-160162-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SR 11023 is an orally active antagonist of PPARγ, with the IC50 value of 109 nM that plays an important role in diabetic research[1].
CAS Number
1820602-13-8
UNSPSC
12352005
Target
PPAR
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/sr-11023.html
Purity
99.55
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
C[C@@H](C1=CC(C2CC2)=CC=C1)NC(C3=CC=C(C(C(C)=C4C)=C3)N4CC5=CC=C(C=C5)C(C)(C)C(O)=O)=O
Molecular Formula
C33H36N2O3
Molecular Weight
508.65
References & Citations
[1]J Mukherjee, et al. Chemical Crosslinking Mass Spectrometry Reveals the Conformational Landscape of the Activation Helix of PPARγ; a Model for Ligand-Dependent Antagonism. Nucl Med Biol. 1995 Apr;22 (3) :283-96.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PPARγ

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