SR-3029

• Description :

  SR-3029 is a potent and ATP competitive CK1δ and CK1ε inhibitor, with IC50s of 44 nM and 260 nM, respectively, and Kis of 97 nM for both kinases.

• UNSPSC :

  12352005

• Hazard Statement :

  H315, H319, H335

• Target :

  Casein Kinase

• Type :

  Reference compound

• Related Pathways :

  Cell Cycle/DNA Damage; Stem Cell/Wnt

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/SR-3029.html

• Purity :

  99.73

• Solubility :

  DMSO : ≥ 30 mg/mL

• Smiles :

  FC1=CC(N2C=NC3=C(NCC4=NC5=CC=C(F)C(F)=C5N4)N=C(N6CCOCC6)N=C23)=CC=C1

• Molecular Formula :

  C23H19F3N8O

• Molecular Weight :

  480.45

• Precautions :

  H315, H319, H335

• References & Citations :

  [1]Bibian M, et al. Development of highly selective casein kinase 1δ/1ε (CK1δ/ε) inhibitors with potent antiproliferative properties. Bioorg Med Chem Lett. 2013 Aug 1;23 (15) :4374-80.|[2]Rosenberg LH, et al. Therapeutic targeting of casein kinase 1δ in breast cancer. Sci Transl Med. 2015 Dec 16;7 (318) :318ra202.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  CK1

• CAS Number :

  [1454585-06-8]