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HDAC3-IN-2

CAT: 0931-T79714-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0931-T79714-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
Apoptosis, Histone Methyltransferase, Caspase, DNA/RNA Synthesis, HDAC
Related Pathways
Cell Cycle/Checkpoint, DNA Damage/DNA Repair, Chromatin/Epigenetic, Proteases/Proteasome, Apoptosis
Bioactivity
HDAC3-IN-2 (compound 4i), a pyrazinyl hydrazide-based HDAC3 inhibitor with an IC50 of 14 nM, effectively targets triple-negative breast cancer cells. Demonstrating cytotoxic activity, HDAC3-IN-2 exhibits an IC50 of 0.55 μM against 4T1 cells and 0.74 μM against MDA-MB-231 cells. In vivo, it shows anti-tumor efficacy in tumor-bearing mouse models by selectively elevating acetylation of histones H3K9, H3K27, and H4K12, enhancing apoptosis-inducing proteins caspase-3, caspase-7, and cytochrome c, and diminishing proliferation markers Bcl-2, CD44, EGFR, and Ki-67 [1].
Molecular Formula
C16H21N5O2
Molecular Weight
315.37
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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