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HDAC3-IN-7

CAT: 0931-T207264-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T207264-01Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
PD-1/PD-L1, HDAC
Related Pathways
Apoptosis, Cell Cycle/Checkpoint, DNA Damage/DNA Repair, Immunology/Inflammation, Chromatin/Epigenetic
Bioactivity
HDAC3-IN-7 (Compound 8ae) is a selective HDAC3 inhibitor with an IC50 value of 311 nM. It effectively induces the degradation of PD-L1 via a cathepsin B-mediated lysosomal pathway, demonstrating the ability to inhibit tumor cell proliferation, migration, and invasion. HDAC3-IN-7 holds potential for cancer research.
Molecular Formula
C25H37N5O4S
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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