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HDAC3-IN-5

CAT: 0931-T89080-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T89080-01Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
Apoptosis, HDAC
Related Pathways
Chromatin/Epigenetic, Apoptosis, DNA Damage/DNA Repair
Bioactivity
HDAC3-IN-5 (9c) is a selective inhibitor of HDAC3, exhibiting IC50 values of 4.2 nM for HDAC3, 1629 nM for HDAC2, and 298.2 nM for HDAC1. In vitro, it effectively induces apoptosis in MV4-11 cells and reduces the expression of anti-apoptotic proteins. The development of selective HDAC3 inhibitors like HDAC3-IN-5 (9c) could serve as potential lead compounds for reversing Venetoclax resistance.
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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