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PROTAC CDK9 degrader-2

CAT: 0931-T17728-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0931-T17728-01Size:100 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2435721-30-3
Target
Others, PROTACs, CDK
Related Pathways
PROTAC, Cell Cycle/Checkpoint, Others
Bioactivity
PROTAC CDK9 degrader-2 (compounds 11c) is a potent and selective CDK9 degrader based on PROTAC, with an IC50 of 17 μM in MCF-7 cell lines. Natural product Wogonin binds ubiquitin E3 ligase cereblon (CRBN) via a linker to form PROTAC[1].
Smiles
O=C(C=C(C1=CC=CC=C1)O2)C3=C2C(OCC4=CN(CCCCCCCC(NC5=C(C(N(C6C(NC(CC6)=O)=O)C7=O)=O)C7=CC=C5)=O)N=N4)=C(O)C=C3O
Molecular Formula
C39H36N6O10
Molecular Weight
748.74
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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