FXR agonist 9

• Target :

  FXR

• Related Pathways :

  Metabolism

• Bioactivity :

  FXR agonist9 (compound 26) is a selective, orally active partial agonist of FXR with an EC50 of 0.09 µM (maximum efficacy of 75.13%) . It ameliorates the pathological features of fatty liver disease in mice induced by HFD and CCl4-related metabolic dysfunction.

• Smiles :

  O=C(O)C=1C=CC=C(C1)NC(=O)C=2C=CC=CC2NC(=O)CCCOC3=CC=C(C=C3)C(C)(C)C

• Molecular Formula :

  C28H30N2O5

• Molecular Weight :

  474.55

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  2982502-32-7