SA09-Cu

• Target :

  Others|||Antibacterial

• Related Pathways :

  Others|||Microbiology/Virology

• Bioactivity :

  SA09-Cu is a potent, noncompetitive inhibitor of NDM-1, with an IC50 of 9.6 nM. It inactivates NDM-1 by oxidizing the enzyme's Zn (II) -thiolate site and resists reduction by bacterial intracellular thiols. SA09-Cu effectively restores Meropenem efficacy against various clinical NDM-1-producing carbapenem-resistant Enterobacteriaceae (CRE) and hampers the progression of carbapenem resistance [1].

• Smiles :

  N(CCO)(C)C=1[S-][Cu+2]2([S-]C(N(CCO)C)=[S]2)[S]1

• Molecular Formula :

  C8H16CuN2O2S4

• Molecular Weight :

  364.03

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  155641-16-0