CU-76

CAT: 0931-T38329Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0931-T38329Size:5 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

2400954-58-5

Target

CGAS, Others

Related Pathways

Immunology/Inflammation, Others

Bioactivity

CU-76 is an inhibitor of cyclic GMP-AMP synthase (cGAS; IC50= 0.24 μM) .1It reduces DNA-, but not Sendai virus-, induced dimerization of IFN regulatory factor 3 in THP-1 cells, indicating selectivity for the cGAS DNA sensing pathway over the RIG-I-MAVS RNA sensing pathway. CU-76 decreases IFN-stimulatory DNA-induced production of IFN-β in THP-1 cells when used at concentrations of 10, 30, and 100 μM.

Smiles

N(C=1N=C(C(OC)=O)N=C(N)N1)C2=CC(F)=C(I)C(F)=C2

Molecular Formula

C11H8F2IN5O2

Molecular Weight

407.11

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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7820/2	CU-76
S8060-11B	Superoxide Dismutase, Cu (SOD Cu)
sc-51698	SLP-76 (SLP-76/03)
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CU50	GHK-Cu
BA6310-5.1	CU-115
QLD34032-01	CU-CPT9a
JJD80575-01	CU-CPT17e
HY-112051-01	CU-CPT9b
MBS3612794-01	CU-CPT22

CU-76

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