CU-76

• Target :

  CGAS|||Others

• Related Pathways :

  Immunology/Inflammation|||Others

• Bioactivity :

  CU-76 is an inhibitor of cyclic GMP-AMP synthase (cGAS; IC50= 0.24 ?M) .1It reduces DNA-, but not Sendai virus-, induced dimerization of IFN regulatory factor 3 in THP-1 cells, indicating selectivity for the cGAS DNA sensing pathway over the RIG-I-MAVS RNA sensing pathway. CU-76 decreases IFN-stimulatory DNA-induced production of IFN-? in THP-1 cells when used at concentrations of 10, 30, and 100 ?M.

• Smiles :

  N(C=1N=C(C(OC)=O)N=C(N)N1)C2=CC(F)=C(I)C(F)=C2

• Molecular Formula :

  C11H8F2IN5O2

• Molecular Weight :

  407.11

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  2400954-58-5