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HDAC-IN-63

CAT: 0931-T78818-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T78818-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2920046-95-1
Target
FLT, Apoptosis, Others, HDAC
Related Pathways
DNA Damage/DNA Repair, Apoptosis, Others, Tyrosine Kinase/Adaptors, Chromatin/Epigenetic, Angiogenesis
Bioactivity
HDAC-IN-63 (Compound 63) is a dual FLT3/HDAC inhibitor with IC50 values of 0.844 nM for FLT3 and 30.0 nM for HDAC1. It effectively suppresses MV4-11 cell proliferation (IC50 of 92 nM), induces apoptosis, and arrests the cell cycle in MV4-11 cells. This compound is applied in acute myeloid leukemia (AML) research [1].
Smiles
C(N1C=2C(N=C1)=CC=C(C2)C3=CC(NC(CCCCCCC(NO)=O)=O)=NN3)C4=C(Cl)C=CC=C4Cl
Molecular Formula
C25H26Cl2N6O3
Molecular Weight
529.42
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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