MTX-23

CAT: 0931-T74744-01Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0931-T74744-01Size:5 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

2488296-74-6

Target

Apoptosis, PROTACs, Androgen Receptor

Related Pathways

Endocrinology/Hormones, Apoptosis, PROTAC

Bioactivity

MTX-23, an AR-targeted Proteolysis Targeting Chimera (PROTAC), effectively degrades both AR-V7 and AR-FL, inhibiting the proliferation of CaP cells and inducing apoptosis [1].

Smiles

O=C(NCCCCC(=O)N[C@@H](C(C)(C)C)C(=O)N1[C@@H](C[C@@H](O)C1)C(=O)N[C@@H](C)C2=CC=C(C=C2)C3=C(C)N=CS3)COC4=C(C=CC(F)=C4F)C5N=C(SC=5)N6CCOCC6

Molecular Formula

C43H53F2N7O7S2

Molecular Weight

882.05

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Chemical Information

PROTAC AR-V7 degrader-2

CAS Number	2488296-74-6
PubChem CID	154612215
IUPAC Name	(2S,4R)-1-[(2S)-2-[5-[[2-[2,3-difluoro-6-(2-morpholin-4-yl-1,3-thiazol-4-yl)phenoxy]acetyl]amino]pentanoylamino]-3,3-dimethylbutanoyl]-4-hydroxy-N-[(1S)-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]ethyl]pyrrolidine-2-carboxamide
Molecular Formula	C43H53F2N7O7S2
Molecular Weight	882.1
XLogP	5.3
Topological Polar Surface Area	232
Hydrogen Bond Donor Count	4
Hydrogen Bond Acceptor Count	14
Rotatable Bond Count	17
Heavy Atom Count	61
Formal Charge	0
Complexity	1470

SMILES

CC1=C(SC=N1)C2=CC=C(C=C2)[C@H](C)NC(=O)[C@@H]3C[C@H](CN3C(=O)[C@H](C(C)(C)C)NC(=O)CCCCNC(=O)COC4=C(C=CC(=C4F)F)C5=CSC(=N5)N6CCOCC6)O

InChI

InChI=1S/C43H53F2N7O7S2/c1-25(27-9-11-28(12-10-27)38-26(2)47-24-61-38)48-40(56)33-20-29(53)21-52(33)41(57)39(43(3,4)5)50-34(54)8-6-7-15-46-35(55)22-59-37-30(13-14-31(44)36(37)45)32-23-60-42(49-32)51-16-18-58-19-17-51/h9-14,23-25,29,33,39,53H,6-8,15-22H2,1-5H3,(H,46,55)(H,48,56)(H,50,54)/t25-,29+,33-,39+/m0/s1

InChIKey

JOZGICGAZBMCJF-JMSDHYLISA-N

Chemical Structure

2D Structure

CAS: 2488296-74-6

CID: 154612215

Formula: C43H53F2N7O7S2

MW: 882.1

Interactive 3D Structure

Loading 3D structure...

View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	882.1
XLogP3	5.3
Hydrogen Bond Donor Count	4
Hydrogen Bond Acceptor Count	14
Rotatable Bond Count	17
Exact Mass	881.34159573
Monoisotopic Mass	881.34159573
Topological Polar Surface Area	232 Å²
Heavy Atom Count	61
Formal Charge	0
Complexity	1470
Isotope Atom Count	0
Defined Atom Stereocenter Count	4
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

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Alternative Products

Catalog	Name
HY-148771-01	MTX-23
A23932-5	MTX-23 (PROTAC AR-V7 degrader-2) 5mg
A23932-10	MTX-23 (PROTAC AR-V7 degrader-2) 10mg
A23932-50	MTX-23 (PROTAC AR-V7 degrader-2) 50mg
A23932-1	MTX-23 (PROTAC AR-V7 degrader-2) 1mg
HY-156872	MTX-216
B1968-25	MTX-211
GTR19230852-01	MTX-241F
C03278-100mg	MTX-531
GTR19236325-01	MTX-3937

MTX-23

Chemical Information

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