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JNK-IN-23

CAT: 0931-T210950-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T210950-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1007786-48-2
Target
JNK
Related Pathways
MAPK
Bioactivity
JNK-IN-23 (Compound K12) is an inhibitor of JNK. It effectively inhibits the proliferation of MDA-MB-231 cells with a GIC50 of 30 nM. In vivo, JNK-IN-23 blocks metastatic growth of triple-negative breast cancer (TNBC) . Additionally, it suppresses the growth of lung metastases by dual targeting of glutaminase-1 (GLS) and the pyruvate dehydrogenase complex (PDHC) .
Smiles
O=C1N=C(NC=2SC(=C(C12)C)C)C(SC=3N=C4C=CC=CC4=NC3C)C
Molecular Formula
C19H18N4OS2
Molecular Weight
382.5
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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