MTX-531

• Target:

  PI3K|||PPAR|||EGFR

• Related Pathways:

  Tyrosine Kinase/Adaptors|||DNA Damage/DNA Repair|||PI3K/Akt/mTOR signaling|||Angiogenesis|||JAK/STAT signaling|||Metabolism

• Bioactivity:

  MTX-531 is a selective inhibitor of EGFR and PI3K with IC50 of 14.7 ? nM and 1.1-233 ?nM (PI3K?, PI3K?...), respectively. It also acts as a weak agonist of PPAR?, with an EC50 of 3.4 ?M in 293H cells.

• Smiles:

  N([C@H](C)C1=CC=CC=C1)C=2C3=C(C=CC(=C3)C=4C=C(NS(C)(=O)=O)C(Cl)=NC4)N=CN2

• Molecular Formula:

  C22H20ClN5O2S

• Molecular Weight:

  453.94

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  2791417-66-6