KTX-582

• Target :

  IRAK|||Apoptosis|||PROTACs

• Related Pathways :

  NF-?B|||PROTAC|||Immunology/Inflammation|||Apoptosis

• Bioactivity :

  KTX-582 is a potent IRAK4 degrader with DC50 values of 4 nM for IRAK4 and 5 nM for Ikaros. It effectively induces apoptosis in MYD88 MT DLBCL and has demonstrated efficacy in inducing in vivo tumor regressions in a lymphoma model [1] [2] [3].

• Smiles :

  CN(CCCO[C@H]1C[C@@H](C1)Nc1cccc2C(=O)N(C3CCC(=O)NC3=O)C(=O)c12)C[C@H]1CC[C@@H](CC1)n1cc2cc(NC(=O)c3cccc(n3)C(F)(F)F)c(cc2n1)C(C)(C)O

• Molecular Formula :

  C45H51F3N8O7

• Molecular Weight :

  872.93

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  2573298-13-0