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KTX-951

CAT: 0931-T74670-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0931-T74670-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2573298-36-7
Target
IRAK, PROTACs
Related Pathways
Immunology/Inflammation, NF-κB, PROTAC
Bioactivity
KTX-951, a PROTAC designed for IRAK4 degradation (DC 50 =18 nM), exhibits an oral bioavailability (F%) of 22% in a rat model at a dosage of 10 mg/kg. Additionally, KTX-951 demonstrates promising anticancer potential [1].
Smiles
COc1cc2nn(cc2cc1NC(=O)c1cccc(n1)C(C)(F)F)[C@H]1CC[C@H](CN2CCC3(CC(CCNc4cccc5C(=O)N(C6CCC(=O)NC6=O)C(=O)c45)C3)CC2)CC1
Molecular Formula
C46H52F2N8O6
Molecular Weight
850.95
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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