KTX-951

• Target:

  IRAK|||PROTACs

• Related Pathways:

  Immunology/Inflammation|||NF-?B|||PROTAC

• Bioactivity:

  KTX-951, a PROTAC designed for IRAK4 degradation (DC 50 =18 nM), exhibits an oral bioavailability (F%) of 22% in a rat model at a dosage of 10 mg/kg. Additionally, KTX-951 demonstrates promising anticancer potential [1].

• Smiles:

  COc1cc2nn(cc2cc1NC(=O)c1cccc(n1)C(C)(F)F)[C@H]1CC[C@H](CN2CCC3(CC(CCNc4cccc5C(=O)N(C6CCC(=O)NC6=O)C(=O)c45)C3)CC2)CC1

• Molecular Formula:

  C46H52F2N8O6

• Molecular Weight:

  850.95

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  2573298-36-7