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KTX-582 intermediate-3

CAT: 0804-HY-49435Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-49435Size:1 Each
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Description
KTX-582 intermediate-3 is an intermediate in the synthesis of KTX-582 and can be used for ADC preparation. KTX-582 is an IRAK4 degrader and inducer of apoptosis with DC50 of 4 nM and 5 nM for IRAK4 and Ikaros, respectively[1].
CAS Number
2573304-30-8
UNSPSC
12352203
Target
Apoptosis
Type
ADC Related
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ktx-582-intermediate-3.html
Solubility
10 mM in DMSO
Smiles
CC(O)(C1=C(NC(C2=CC=CC(C(F)(F)F)=N2)=O)C=C3C=NN([C@@H]4CC[C@H](CC4)C(OCC)=O)C3=C1)C
Molecular Formula
C26H29F3N4O4
Molecular Weight
518.53
References & Citations
[1]Mainolfi, et al. Preparation of heterocycles as IRAK degraders and uses thereof. World Intellectual Property Organization, WO2020264499 A1. 2020-12-03.
Shipping Conditions
Room temperature
Scientific Category
ADC Related
Clinical Information
No Development Reported

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