KTX-582 intermediate-3

• UNSPSC Description:

  KTX-582 intermediate-3 is an intermediate in the synthesis of KTX-582 (HY-148274) and can be used for ADC preparation. KTX-582 is an IRAK4 degrader and inducer of apoptosis with DC50 of 4 nM and 5 nM for IRAK4 and Ikaros, respectively[1].

• Target Antigen:

  Apoptosis

• Type:

  ADC Related

• Related Pathways:

  Apoptosis

• Applications:

  Cancer-programmed cell death

• Field of Research:

  cancer

• Assay Protocol:

  https://www.medchemexpress.com/ktx-582-intermediate-3.html

• Solubility:

  10 mM in DMSO

• Smiles:

  CC(O)(C1=C(NC(C2=CC=CC(C(F)(F)F)=N2)=O)C=C3C=NN([C@@H]4CC[C@H](CC4)C(OCC)=O)C3=C1)C

• Molecular Weight:

  518.53

• References & Citations:

  [1]Mainolfi, et al. Preparation of heterocycles as IRAK degraders and uses thereof. World Intellectual Property Organization, WO2020264499 A1. 2020-12-03.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2573304-30-8