SEH/AChE-IN-4

CAT: 0931-T72876-01Size: 25 mgDry Ice: NoHazardous: No

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CAT#:0931-T72876-01Size:25 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

2490589-12-1

Target

Others, Epoxide Hydrolase, Cholinesterase (ChE)

Related Pathways

Metabolism, Others, Neuroscience

Bioactivity

SEH/AChE-IN-4 -15 is a potent, blood-brain barrier-penetrating dual inhibitor targeting soluble epoxide hydrolase (sEH) and acetylcholinesterase (AChE) . It demonstrates notable inhibition efficacy, with IC50 values of 3.1 nM (hsEH), 1660 nM (hAChE), 179 nM (hBChE, human butyrylcholinesterase), 14.5 nM (msEH), and 102 nM (mAChE), indicating its significant inhibitory action across both targeted enzymes in human and mouse models.

Smiles

N(CCCCC(=O)N1CCC(NC(NC2=CC=C(OC(F)(F)F)C=C2)=O)CC1)C3=C4C(=NC=5C3=CC=C(Cl)C5)C[C@]6(C[C@@]4(CC(C)=C6)[H])[H]

Molecular Formula

C35H39ClF3N5O3

Molecular Weight

670.16

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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Alternative Products

Catalog	Name
HY-145833A	SEH/AChE-IN-4
HY-145831	SEH/AChE-IN-1
MBS5815131	sEH/AChE-IN-3
MBS5815130	sEH/AChE-IN-2
GTR19184928-01	SEH inhibitor-4
HY-179166	PROTAC sEH-degrader-4
HY-157441	AChE/Aβ-IN-4
HY-145235	AChE-IN-4
HY-174327	SEH-IN-3
MBS5774523	sEH-IN-12

SEH/AChE-IN-4

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