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SEH/AChE-IN-1

CAT: 0804-HY-145831Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-145831Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SEH/AChE-IN-1 (Compound 12a) is a dual inhibitor of the enzymes soluble epoxide hydrolase (sEH) and acetylcholinesterase (AChE) . sEH/AChE-IN-1 provides cumulative effects against neuroinflammation and memory impairment. sEH/AChE-IN-1 has the potential for the research of Alzheimer's disease (AD) [1].
CAS Number
2490589-08-5
UNSPSC
12352005
Target
Cholinesterase (ChE)
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/seh-ache-in-1.html
Solubility
10 mM in DMSO
Smiles
ClC1=CC2=C(C(NCCC(N3CCC(CC3)NC(NC4=CC=C(C=C4)OC(F)(F)F)=O)=O)=C5C(CCCC5)=N2)C=C1
Molecular Formula
C29H31ClF3N5O3
Molecular Weight
590.04
References & Citations
[1] Codony S, et al. Discovery and In Vivo Proof of Concept of a Highly Potent Dual Inhibitor of Soluble Epoxide Hydrolase and Acetylcholinesterase for the Treatment of Alzheimer's Disease. J Med Chem. 2022;65 (6) :4909-4925.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
AChE

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